Bioinformatics Core Collaborations
We are currently supporting the following projects through our interdisciplinary and collaborative research program. Some of these projects are listed below:
The Breast cancer biomarker discovery and target validation
This is a collaborative project whose mission is to enhance understanding of the molecular mechanisms leading to development and progression of breast cancer, with the ultimate goal of identifying targets for early theureputic intervention and drug design. This is in collaboration with Miele lab, Cancer institute, UMMC Jackson MS.
The Population genomics of cancer health disparities using genotype, genomic and sequence data
We are using computational approaches to dissect the genetic architecture of breast cancer, and to elucidate the molecular mechanisms contributing to cancer health disparities in different populations. This is done in collaboration with Miele lab and Dr. Tom Mosley (Memory Impairment and Neurodegenerative Dementia [MIND] Research Center and Atherosclerosis Risk in Communities [ARIC] study).
Neurodegenerative diseases
Our key focus is identification and functional characterization of genetic markers and epigenetic factors associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and vascular dementia. We use integrative bioinformatics approaches to analyze genomic, epigenomic and imaging data to identify molecular signatures and biological pathways involved in neurodegenerative diseases, and to elucidate the effects of SNPs and CNVs on gene and protein function. This is done in collaboration with Dr. Tom Mosley (MIND Center and ARIC study).
